The „XPAMAC technology” is an exceptionally efficient cell line development method, leveraging the Mammalian Artificial Chromosome (MAC) technology. It rapidly creates stable, silencing-free mammalian cell lines, setting a new standard with its leading constant protein yields. In the XPAMAC cell lines, the transgene is inserted with unparalleled efficiency into a safe-harbor genomic location, providing robust protection against silencing. The number of inserted gene copies can be precisely controlled in the range of 1-100 with our proprietary selection and amplification protocol. XPAMAC delivers silencing-free constantly high-protein yield cell lines within a remarkably short span of 8 weeks. The technology is compatible with all industry-standard CHO and human cell lines, ensuring efficient protein production.
The gene integration and amplification technology of XPAMAC is not only innovative, but also protected by patent applications worldwide. We are continuously developing the technology and file further patent applications to secure intellectual property rights, ensuring well-protected investment.
Extending Boundaries of Protein Therapies